One collar. Eight months. No monthly reminders.

Seresto Find your size

4.5 from 115,226 ratings

Seresto Flea & Tick Collar for Large Dogs Over 18 lbs

The collar for dogs heavier than 18 lbs. It kills and repels fleas and ticks by contact, so a pest does not have to bite to die, starts within 24 hours and keeps going for 8 continuous months — no greasy drops, no monthly reminder.

$49.99

Key features

  • For dogs and puppies over 18 lbs
  • 8 continuous months per collar
  • Works by contact — no bite needed
  • Starts within 24 hours
  • Non-greasy, unscented, no prescription
Choose
  • Delivered by the store you order from
  • Returns through your order
  • No prescription needed
What is inside
Active ingredientsImidacloprid, Flumethrin
Protection8 continuous months
Starts workingWithin 24 hours
FormNon-greasy collar, unscented
Dog sizeOver 18 lbs
Weight3.84 oz per collar
Packs1 or 2 collars
Good to know

Two dogs, or one dog for 16 months? The 2-collar pack covers both.

How the Seresto collar works on large dogs

Large Dog Collar

How the Seresto collar works on large dogs

A Seresto collar releases its two active ingredients, imidacloprid and flumethrin, slowly from the collar into the coat. Fleas and ticks are killed and repelled on contact, which means they do not need to bite your dog first. Once the collar is on, protection starts within 24 hours and continues for 8 months, so one collar covers most of a flea and tick season. It kills fleas and ticks across the whole dog, from the neck to the tail, as long-lasting flea and tick prevention for dogs and puppies 7 weeks old and older.

Fitting the Seresto collar on a big dog

Large Dog Collar

Fitting the Seresto collar on a big dog

Put the collar around the neck, push the end through the buckle and adjust the fit as the label describes; then trim the extra length. Write the date down — the collar gives tick protection and flea control for 8 months, and then it is time for a new one.

Vet-recommended without a vet visit

Large Dog Collar

Vet-recommended without a vet visit

Seresto is described by its maker, Elanco Animal Health, as the #1 veterinarian-recommended flea and tick collar. It needs no prescription, leaves nothing greasy on the fur and has no scent.

What owners say

This really helped with the fleas!!

Now this worked! After trying natural plant based collars to get rid of fleas and larvae to no avail. I had to go to this. I am not a fan of medicated collars, but we had to use something a bit stronger. So after using Wondercide shampoo, I put these on my pups. They worked. I didn't notice anymore scratching, and both dogs seemed much happier. I din't notice any alarming side effects or lethargy. No scent was nice too

AGSeptember 28, 2026 · Large Dog Collar

Quick answers

How long does it last?

One Seresto collar works for 8 continuous months and starts within 24 hours.

Which size do I need?

Dogs over 18 lbs: large dog collar. Dogs under 18 lbs: small dog collar. Cats and kittens: the cat collar.

Is a prescription needed?

No. Seresto is sold without a prescription.

You may also like

Under 18 lbsSeresto Flea & Tick Collar for Small Dogs Under 18 lbs

Small Dog Collar

55,096

For dogs and puppies under 18 lbs

from $59.92

2 options

CatsSeresto Flea & Tick Collar for Cats and Kittens

Cat Collar

47,340

For cats and kittens 10 weeks and older

from $49.99

2 options

9 setsSeresto Large Dog Collar + Pet Protect Supplement Sets

Large Dog Sets

Seresto large dog collar, 8 months

from $69.91

9 options